All gates closed, as otherwise the flow may deposit silt and other debris on the cills, preventing the gates from closing properly (and so wasting more water).
One or both paddles each end. The former is easier, the latter may fill (or empty) pounds quicker.
If I'm on my own and going uphill through a series of low pounds I usually walk up 2 or 3 locks and open one paddle each end, then return to the boat and work through, leaving the lock as soon as I am confident I can get out over the top cill without touching - no need to wait until the pound is full to weir level. The pound is usually shallower than the cill, so I tend to bounce my way through, sometimes having to wait a bit longer for the level to rise further. The aim is to get through those next 2 or 3 locks with just enough water to get through, so I don't take too much water from fuller pounds ahead.