If the Kennet is flowing there are a number of pinch points betweeen Reading and Kintbury. The first one is the bridge at Burghfield just before the 14 day moorings for the Cunning Man pub.The approach to Tyle Mill can be slow but the lock landing is in still water so not normally an issue. Great moorings past Tyle Mill on the meadows. Going upstram at Woolhamptom don´t aim straight at the lock, stay as far right as you can then aim straight for the incoming stream which will hopefully end up with the bows in the lock mouth. Newbury town lock has a strong flow under the bridge. Personally I would want to do a recce, on the left hand side is a concrete shelf, if that is underwater I personally wouldn´t bother trying but that is on an 18ton narrowbaot with 35hp your Sea Otter may have a better power to weight ratio.
Cheap Coal and Diesel at Pinnocks if you moor at Thatcham before Monkey Marsh lock.
Moorings are not an issue, apart from the approaches to Bradford and Avon, but in March you willl have no problems.As BillS says above dont expect to be able to get the front and back in at the same time but otherwise not a problem.The Eastern side IMHO is a gem, don´t be surprised not to see another boat moving, lock queues are unheard of and the scenery is beautiful. Enjoy.