I have done a lot of research on this, visiting many adapted boats and working with lots of folk over the years in my vested interest with many boaters of all abilities with disabledboaters.org. Yes there are compromises to be made, I lived on a former hire boat which we have just sold which restricted me even further meaning when legs not working I was literally trapped at times legs not working.
Lyneal trust is one of the organizations that has adapted boats for holidays, (yes I know different to livaboards) and it works well.
I am very lucky to be building from scratch so can incorporate a wheel chair lift into a boot room or boatmans cabin area at about 4 foot long. then in to a galley with narrower cabinets on one side and full side on the other allowing good wide passage through and loads of storage at the same time, saloon will have an already adapted sofa I had made by elite furnishings and lift off tables, then a walk through wet room with appropriate fittings and sliding doors, then 2 bedrooms with single beds so accessible for chair and help if needed to get onto beds. follow through to snug or study come dressing room in the extended cabin. all planned out to leave turning circles in boatmans cabin space, saloon. wet room and bow cabin.
If anything this boat will defo have a lot more storage, and more usuable space than my old boat. and be a lot less restrictive, as I can design from scratch to my personal needs.
Bottom line is with a bit of research and thought it is extremely doable , no different from bricks and mortar in that respect,