There are plenty of boatyards that will offer shortbreaks generally starting on a Friday or Monday. I would start by using one of the agency booking sites to see what is available. If it was me, for a shortbreak I would be looking at a start point that was not too far from home or maybe in the middle of where you are all based! That will also give you an idea of the different boats. Most hirebases also suggest routes from their base.
And by the way don’t worry about locks they’re all part of the fun.